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{July 03, 2009}   Cancer of the Mesothelium Sufferers Might Find Hope from Clinical Trials of New Treatments

Cancer doctors determine what type of treatment to pursue for each patient. There are many options. There is no universal treatment regimen for peritoneal mesothelioma patients. This is due to the cancers high mortality rate, rareness, low treatment success rate, and small number of studies to provide meaningful statistics.

The prospects for mesothelioma patients have been grim, but doctors have recently made progress. Treatments for cancer are traditionally surgery (taking out the tumor and surrounding tissue), radiation (killing the cancerous cells with radiation), and chemotherapy (poisoning the cancerous cells.) All three methods have problems. Mesothelioma patients treated with traditional radiation therapy have not responded well to it. Researchers are looking for ways of aiming radiation directly at the tumor in hopes that this will result in less damage to healthy tissue.

Surgery takes out the mesothelial cancerous tissue around the tumor. This surgery is extensive and it is not clear how much the patient benefits. Most chemotherapy medication that work on other cancers typically do not work on mesothelioma, and different combinations of chemotherapy drugs have been tried without a lot of success. Like radiation, researchers are focusing their work on controlling the physical location of the treatment with an emphasis on the pleural cavity.

The death rate for mesothelioma is so high that many of even the most sophisticated techniques in cancer treatment are tried out on patients. Such treatments include anti-angiogenesis drugs like thalidomide and biologic therapies agent interleukin 2. The new drug pemetrexed (brand name Alimta) has shown good results in extending life with mesotheliomas..

Considered by oncologists is where the tumor is located, what stage the mesothelioma is in, and the age and health of the patient. Theres also photodynamic therapy and gene therapy ” two far-out new ways of attacking cancer. Patients afflicted with mesothelioma are benefitting in these clinical trials.

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